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Excessive training causes mitochondrial damage and glucose intolerance

🔥Check out this cool, recent study on the potential effects underlying "overtraining".


🕵🏻The results are super intriguing. Also absolutely love the research group that published this paper and the meticulousness that goes into their analysis. Despite that, I'm not sure I can follow all of their interpretation of the data.


🤔For example, I am not fully convinced the decrease in circulatory lactate and glucose during the ET sessions can be taken as a sign for disturbed glycolysis.


⬆️⬇️Yes, levels could be lower as a function of impaired glycolysis as would be supported by higher glycogen levels and lower performance. But there is a number of other ways to explain lower circulatory glucose levels. Among them also a scenario of increased glucose utilization by muscle and liver.


👩🏽‍🔬Anyway, cool stuff. Future studies will yield more comprehensive insights. Make sure to check out the actual study to dive a little deeper into the data. Let us know if you need help with accessing it.


Reference:

Flockhart et al., Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab. 2021 May 4;33(5):957-970.e6.

PMID: 33740420






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