š„Another WOD Science original!
š§¬This time on changes in anabolic signaling with repeated resistance exercise.
šš½āāļøBottom line: Once again, acute molecular changes seem to be rather poor predictors of chronic changes and adaptations in skeletal muscle. This is not the first time that we found that some of the chronic signals are even opposite of what they look like acutely.
š§«In this case, mTORC1 activity might be overrated as a regulator of physiological adaptations to resistance exercise and muscle growth. Our data also supports the idea that for muscle growth and maintenance, you likely want growth signals through mTORC1 to be transiently activated rather than constantly activated. It's all about balance and constitutively increased mTORC1 seems to do more harm than good.
šš¼Drop any questions you may have in the comments section!
š§¾Reference:
Langer HT et al., Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling. Sci Rep. 2022.
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